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Of the commonly used staging systems, the METAVIR fibrosis score has been widely used (Huwart et al., 2008)

Appetite and sleep: Appetite suppression and insomnia commonly last 12 to 24 hours beyond the primary high as residual dopamine and norepinephrine activity persists

When low-and-slow dosing (or staying at the starting dose) makes sense and why not everyone needs aggressive escalation

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This formula can be administered via IV, IM, or SubQ injection